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See the Supplementary Material for more technical details.
The methods used are set out below (see supplementary technical appendix for full details).
The probability of the event of interest must be estimated by taking into account the probability of the competing events; ignoring the competing risks leads to a biased estimation of the probability of the event of interest (see Appendix 1 of the Supplementary Material for more technical details).
We notably rely on principal component analysis (PCA) (Jolliffe, 1986 ; Nikerel et al., 2009 ) applied to the data matrix Y to reduce the model order, i.e. the number of independent parameters, and ensure well-posedness of the regression problem (see Supplementary Section S1 for technical details).
In terms of the model, a similar effect is achieved under the assumption that about 3 to 4% of the stem cells are additionally activated from A into Ω during each simulation time step measuring 1 h (IFN α-mediated activation, for technical details see Supplementary Materials and Supplementary Figure 2).
Supplementary Information: A supplementary document describes the theoretical and technical details about the library implementation.
Please refer to Supplementary Text 2 for the technical details.
Six main scenarios are described in Table 1, with more technical details in supplementary material.
(For full details see supplementary technical appendix table 13.1 or table 1 in Meng et al 16).
We adjusted for future beverage specific retail price indices using estimates provided by the Home Office (for details see supplementary technical Appendix table 5.3).
A representative tumour section was selected from a HE section of the paraffin block with the centre and representative region of tumour tissue identified (detailed in Supplementary Technical Notes).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com