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We also designed a second, supplementary study to monitor serum COMP with repeated measurements after the exercise session.
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We believe that this protocol has the potential to support supplementary studies aiming to promote knowledge regarding two of the most important public health problems from different perspectives: harmful alcohol consumption and domestic violence.
In addition to the CBA, in some areas supplementary studies have to be prepared, analyzing effects which are difficult to valuate (e.g. some environmental aspects).
The plan supported interagency marine resource managers in the structured implementation of a science program by communicating to the public a suite of performance measures and essential and supplementary studies designed to document changes in fisheries resources.
Supplementary studies responding to the above criteria were thus identified, as in a "snowball" approach.
A supplementary study was conducted in order to study if the increased amount of anthocyanins was related to the gene expression of flavonoid pathway genes in bilberries (Additional file 1).
To further examine the changes in serum COMP after exercise we performed a supplementary study with more frequent measurements to elucidate the kinetics of serum COMP during the time immediately following the exercise session.
In a second supplementary study 7 individuals were subjected to the same exercise program and sampling of blood was performed at fixed intervals before, immediately after, 30 and 60 minutes after the exercise session and then with 60 minutes interval for another five hours after exercise to monitor the short-term changes of serum COMP.
However, there is an absence of definitive guidance regarding when to pursue supplementary studies, in part due to ill-defined criteria of what constitutes an adverse effect and to surgical/technical monitoring limitations of study designs.
Supplementary studies were used to define a knocked-down stress strain curve, and to show that using base case results is conservative for more complex situations.
A supplementary study [ 11] validated this rule to predict a composite definition of SCAP (in-hospital death, mechanical ventilation, or shock) in three cohorts including 2,897 patients and 252 SCAP (8.7%).
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