All 21 hospitals were invited to participate in our supplementary study on the completeness of incident reporting systems.
We thank Pedro Cano and Seth Myers for piloting supplementary studies of word recurrences, Roger Guimerà and Seth Myers for sharing web mining programs, Bruce Spencer for advice on the statistical analysis, Stefan Kaufmann for his assistance in developing the semantic coding scheme, and Hannah Rohde for validating it.
For a supplementary study with ambulatory measurements of BP and physical activity, four of the nine organizations were involved.
For the supplementary study with ambulatory measurements of BP and physical activity, for which a much smaller sample size was aimed at, 182 participants were included, indicating a response rate of 66%.
In the course of conversations conducted in the field, we came face to face with a phenomenon that, while it was unrelated to our research objectives, raised ethical and clinical concerns that struck us as sufficiently fundamental to form the focus of a supplementary study.
A supplementary study indicated that maximum purging of gut contents occurred over 24 h with 77% of the soil gut contents being eliminated (unpublished data).
Nevertheless, supplementary nested study of the corresponding germline DNA, derived from peripheral blood leukocytes of the cases where such material was available, was performed to provide confirmation of the constitutional character of the analysed SNPs.
Furthermore, as can be seen in Figure 3, Figure 4, supplementary studies demonstrated the viability of the intended objective of the analytical procedure.
In accordance with that, we found in supplementary studies that the effect was of minor importance for [N-methyl-11C]mirtazapine, being less than 3%.
