Both lowly expressed genes and lowly interacting proteins showed no evidence for TE selection, and the difference between the groups was significant (supplementary table S3, Supplementary Material online).
Also, correlations between rearrangements and the proportions of introns and intronic ORFs were not significant (supplementary table S2, Supplementary Material online).
ALDOB was found to have a higher evolutionary rate in polar bears, but this was not significant (supplementary table S7, Supplementary Material online).
GO analysis revealed nine processes (representing 27 genes) that were significantly enriched within this gene set, with "pathogenesis" (GO 0009405) being the most highly significant (supplementary table S7, Supplementary Material online).
The log2-ratios of fold changes did not show consistent expression levels among species and most of the log2-ratios were not significant (supplementary table S10, Supplementary Material online).
The absolute correlation coefficient values also indicate that the correlations between protein evolutionary rates and promoter/gene body methylation levels are greatly influenced by NTF and NmiR, although all the correlations remain significant (supplementary table S2, Supplementary Material online).
We found that about half of the experimentally generated breakpoints are within 1 kb of an evolutionary breakpoint, although the collocation of these two types of breakpoints is not significant (supplementary table S12, Supplementary Material online).
Post hoc analysis showed that mean GFR and mean CrCl were higher for micafungin vs standard care at most time points during prophylaxis, although differences were not statistically significant (Supplementary Appendix 2.5 and Supplementary Figure 4).
All other alternative sister pair and whole tree analyses were not significant (supplementary tables S1 and S2, Supplementary Material online).
The standard deviations indicated by the error bars show that most of the differences are not significant (supplementary fig. 1 [ Supplementary Material online] shows the analysis of each genome separately).
