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As shown in Fig. 2 the review process was performed in two steps, namely basic and supplementary search.
In this context and in order to improve the initial, basic search, we performed a supplementary search process (the search was performed in March 2017), where in the partial search strings were firstly defined and then performed on both the Science Direct and Scopus databases.
A supplementary search was conducted using Google Scholar.
The supplementary search resulted in a further 272 articles for consideration.
Where Cochrane data were not available we performed a supplementary search for placebo-controlled trials.
Funding schemes required a supplementary search to achieve adequate depth and coverage.
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Search engines such as Google and Scirus are difficult to search comprehensively, but they can be used for supplementary searching to locate potentially useful studies.
We also conducted supplementary searches of the references in retrieved articles.
The CLUSTER procedures systematize and formalize existing processes and assign a clear responsibility for supplementary searching.
This will help identify areas where evidence is lacking and supplementary searches may be necessary.
The searches were conducted in March 2010, with supplementary searches in Embase, Medline and Cochrane Library on 6 May 2010.
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