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I suggest that the authors provide a similar circuit roadmap as supplementary figure, to provide a reference for the reader to follow throughout the paper.
ENCODE21 and Roadmap Epigenomics22 chromatin profiles: files listed in Supplementary Table 1 of ref. 4. IGAP age at onset survival16,17: https://www.niagads.org/datasets/ng00058 (P-values-only file).
For comparison purposes, we downloaded ChIP input, H3K27ac and H3K27me3 data from 3 human iPSC lines (iPS 6.9, iPS-18a, and iPS.20b, all of them release 5) generated by the Roadmap Epigenomics Consortium (Roadmap Epigenomics Consortium et al., 2015) from the NIH GEO database (Supplementary file 6).
According to the methylation states of gametes, early embryos, placentas and human skin tissue (Roadmap dataset), 24 regions were confirmed as germ-line ICRs in humans (Supplementary Table S6 and Figure S5a), 16 of which were conserved between humans and mice, while 8 were human-specific ICRs.
Relationship to NASA Astrobiology Roadmap and Strategy documents and the European AstRoMap Appendix I Appendix II Supplementary Materials References A workshop was held August 26 28, 2015, by the Earth-Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology.
Supplementary Media.
Supplementary information.
Supplementary Material.
Supplementary material.
Supplementary Texts.
Supplementary Materials.
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