Sentence examples for supplementary regulatory from inspiring English sources

These results suggest that the deleted sequences contain supplementary regulatory elements that would promote exon recognition.

Last, two physically close cancer-associated SNPs (3726 a→g and 3743 c→t) resulted in supplementary regulatory elements (IRES and LOX-15-DICE, respectively) in the 3'-UTR of brain-type glycogen phosphorylase, a proposed biomarker of gastrointestinal tumours [ 47, 48].

An element dedicated to long-range activity has been identified in Drosophila (Swanson et al., 2010); we suggest, here, that there is no specific element within the ZRS but rather that long-range activity is due to supplementary regulatory information that boosts the regulatory response.

Up to now we have detected 16 SRE variants (two of them artificial variants) [ 14] of which five are placed in BRCA2 exon 5 suggesting that regulation of some exons strongly depends on supplementary cis-regulatory elements such as ESE or ESS.

In total, 532, 116, and 104 of the candidate human-specific binding sites for NANOG, OCT4, and CTCF, respectively, were found located within long interspersed nuclear element (LINE) and long terminal repeat (LTR) sequences, suggesting that retrotransposons play a significant role in the creation of human-specific regulatory sequences (supplementary data sets S4 S6, Supplementary Material online).

This pattern was not accounted by a bias in our methods of detecting potentially more conserved regulatory regions (supplementary data set S1 and results, Supplementary Material online) nor does it reflect a distribution bias for Helitron insertions in the genome (supplementary data set S2 and results, Supplementary Material online).

Similarly as in the case of DNA duplex stability data, we combined nucleosome data with conservation (supplementary Figure (e)) or regulatory potential data (supplementary Figure (c)), and the combined data again improve the TF target gene predictions.

Among these PSSMs, binding sites of 6 transcription factors can be found within the identified microRNA regulatory regions (Supplementary Table S3).

We find consistent results among different representations of the same regulatory system (Supplementary Figure S8).

The BAN shows some highly interconnected genes and their regulatory miRNAs (Supplementary file 2).

A comparable mutational analysis using larger deletions (100/500 nt) spanning most of the upstream intron did not yield any candidate intronic regulatory element (Supplementary Figure S3).