As previously mentioned, 48 CYP450s were identified in the H327 genome and the majority is potentially involved in phytopathogenesis or toxin production (supplementary table S8, Supplementary Material online).
In addition to Module 5, two other modules (Modules 9 and 72) with a D value more than 0.5 are also mainly involved in energy production (supplementary table S5, Supplementary Material online).
Similar to C. burnetii, CRt contains all genes for the TCA cycle and glycolysis except the first step involving the conversion of glucose to glucose-6-phosphate, suggesting that CRt can use carbohydrates as a carbon source for energy production (supplementary fig. S3, Supplementary Material online).
Additionally, all genes responsible for the degradation fatty acids through the beta-oxidation pathway are pseudogenized in CRt and missing in CLEAA, which means that CRt and CLEAA might not utilize fatty acids for energy production (supplementary fig. S3, Supplementary Material online).
However, no change in either ROS production (Supplementary Figure 3a) or ATM activation (Supplementary Figure 3b) was observed in YAP1-overexpressing glioma cells upon Chaetocin treatment.
We found that APP tg mice and CDK5+/−/APP tg mice showed similar levels of APP expression and A β production (Supplementary Figures 3A, E, and F and Supplementary Figure 4).
During the priming phase, we observed that SKAP55-deficient CD8+ cells reduced IL-2 production (Supplementary Fig S1A) but did not affect LFA-1 (i.e. CD11a) expression (Supplementary Fig S1B).
However, in the present model, neither ROS production (Supplementary Figure 5a) nor the inhibitory effect of antioxidants in CB irradiation-induced glioma cell death was confirmed (Supplementary Figure 5b).
As previously observed, some iNKT cell clones displayed variable reactivity to CD1d-transfected APCs in the absence of exogenously added synthetic antigen, which manifested as significant secretion of IL-13 and GM-CSF and little or no IFNγ production (Supplementary Figure S1).
E, did not reduce ROS production (Supplementary Figure 1A).
