LSD1aP2-Cre mice showed a complete absence of white fat pads (Supplementary Fig. 8a).
By contrast, PPARγ2 is absent in the uterus but induced by DES in the fat pad (supplementary material Fig. S2B).
PPARγ1 is induced by DES in neonatal uterus, but is suppressed in abdominal fat pad (supplementary material Fig. S2B).
However, in KORA F4, neither Lp(a) concentrations nor the frequency of LMW apo(a) phenotypes differed significantly between participants with and without PAD (Supplementary material online, Table S1 ).
Cell movement was also observed in cells attached to the glass surface in liquid medium, proving that movement is not a consequence of physical constraint imposed by the cover slip in agar pads (supplementary material Movie 5).
In order to generate full solid reconstructions of vascular volumes we implemented methods to fill vessels as illustrated in Supplementary Fig. 4. Images were padded with their reflection at all borders to minimize problematic border effects in the different image processing steps.
Subjects with AAA were more likely to be men and had a higher prevalence of heart disease and stroke than subjects with PAD or CAS (Supplementary Table 1).
Strikingly, microscopic observation over many hours revealed amoeboid-like movement of RP-pck2Δ cells on agar pads (Fig. 2A; supplementary material Movie 4) (Webb and Horwitz, 2003; Yanai et al., 1996).
For synovium and fat pad, this meQTL was independent of gender (Supplementary Material, Fig. S4B), although we observed a reduction in fat pad methylation in males relative to females that was independent of genotype (P = 0.009; Supplementary Material, Fig. S4).
Though it is slightly incongruous to pad out a Jacobean drama with supplementary material by Burt Bacharach, the unexpected combination of easy-listening and difficult-watching makes a striking disjunction nonetheless.
Thirty volunteers (15 male, 15 female) typed a standardized text passage while seated at a computer workstation in five backrest configurations: chair only, chair with a supplementary backrest, and with each of three lumbar pad thicknesses.
