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Health-related quality of life (HRQoL) has increasingly been accepted as a supplementary outcome measure for patients after lung transplantation (LTx).
DDD was used as a supplementary outcome measure.
For both interventions, supplementary outcome measures will be chosen from the variables presented in Table 1.
As a further supplementary outcome we also calculated the ICER relative to the next most effective strategy using cost per QALYs.
An important supplementary outcome of medical interventions and the processes of health care is health-related quality of life (HRQOL) [ 3, 4].
Our choice of supplementary outcome variables reflecting functioning in a broader sense, e.g. mobility, ADL and place of residence, will enable us to shed light on other potential effects of an orthogeriatric service.
We will present the output from these surveys to the Steering Committee (SC) who will endorse which core and supplementary outcome variables will be recommended for collection in the main study.
Five trials of oseltamivir were also included, 10 24 31 33 38 one 10 with supplementary outcome data from previous trials and another 24 linked to a redundant publication 38 (totalling 1118 participants in the treatment arm and 679 controls, with a mean length of follow-up of 21 days).
The primary outcome and supplementary PROM outcome will be blinded to the data collectors and data assessor (SR) throughout the trial, since all questionnaires will be answered at the patient's home.
Similar nonsignificant trends were observed for HbA1c for other outcomes (Supplementary Table 4).
All the early factors under study were associated with educational attainment at the age of 28 years as well as with the psychiatric outcomes (Supplementary table 1).
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