Women within the supplementary health network (those who used health plans) or those who paid the expenses of their own childbirth were considered to be part of the private sector.
The edges from the most differentially correlated hub sub-networks were then used as the classification features and each edge was quantified by the expression difference between the hub gene and interactor gene joined by the edge (Additional File 1 - Supplementary methods: Network-based feature selection methods focusing on sub-networks - Taylor's approach and BSS/WSS).
The full content of the first release of the CBN database is summarized in the Supplementary data, including network name, biological process, network description, version and network icon.
We found that the level of selective constraint of physically interacting proteins is more similar than expected from a random network (supplementary table S7, Supplementary Material online).
The ω-degree correlation is significantly higher for proteins in functional categories "signal transduction mechanisms" (P = 0.009) and "chromatin structure and dynamics" (P = 0.025) than for the rest of the network (supplementary table S2, Supplementary Material online).
Single mutant fitness and connectivity were also correlated with d N/d S, indicating that genes with small effects on fitness and fewer numbers of connections tend to evolve more quickly than other genes in the yeast interaction network (supplementary table S2, Supplementary Material online).
This is also observed for the estimations obtained with BCA (fig. 6) and hybridization network (supplementary fig. S4, Supplementary Material online).
Although some short fragments, shared between composite and component sequences, were identified, that is, the minimal ones measuring 25 amino acids, in general hits lengths between composite and component genes were slightly larger than hits lengths in the overall network (supplementary fig. S1, Supplementary Material online).
Finally, the rooted consensus recombination network (supplementary fig. S4, Supplementary Material online) for all the gene trees also shows a pattern of recombination during the radiation of the group (blue lines) and between same-species strains, except for the non-SFG ones.
