We also replicated several associations reported previously with baseline obesity metrics (Supplementary Table 4).
Additional investigation (see online Supplementary Material for metrics) shows that MTI and KNN are capable of reproducing both general and specific MeSH terms.
According to the site-specific differences in correlations between exposure metrics (supplementary table S6) they capture different sources of air pollution and thereby different components.
Of 13 259 participants with first and second spirometry living in ESCAPE monitoring areas, 7615 and 4233, respectively provided complete datasets towards analysis of NO2/NOx/traffic indicators and PM metrics (supplementary figure S1).
We have also developed a collection of open source Java and Perl software for processing the data and obtaining a rich set of metadata and quality metrics (Supplementary Data; Analysis Pipeline).
All analyses controlled for age and QA metrics (see Supplementary Table S1 for unadjusted correlations; Supplementary Data are available online at www.liebertpub.com/brain).
We presented the performance using 'optimized metric' for different metrics in Figure 7 (and Supplementary Fig. S4).
We demonstrated high accordance between node degree and nodal efficiency, whereas node betweenness had lower correlation to other metrics (see supplementary Figure S2).
For additional information, usage and software requirements, see the GenePattern help document provided as Supplementary Material 1. Metrics reports are provided in HTML for human consumption, as well as tab-delimited text files for pipeline integration.
Finally, 10 teams in SC2 and 5 teams in SC3 submitted predictions that were statistically significantly different from random in two of the three metrics used (Supplementary Tables S1 S3).
