Human-specific NANOG-binding sites appear enriched near pluripotency lncRNAs (table 2): They were found in close proximity to 15 pluripotency lncRNAs, whereas CTCF-binding sites were detected in only four instances (supplementary fig. S6, Supplementary Material online).
Overall, collateral responses were observed in 39% (233/590) of possible instances (Supplementary Table 2); of these 49% (115/233) were associated with only a 1.5-fold change in IC90.
Overall CR was more frequent than CS, 141 versus 92 instances (Supplementary Table 2), and collateral networks varied considerably between resistance groups.
The final 'reduced' ELM data are hereon referred to as reduced ELM (ELMred) definitions and instances (Supplementary Table S1).
In Supplementary Table S4, instances in some clusters, such as IL1B/IL1R1 (No. 62) (also shown in Figure 1A), RAC1/TIAM1 (No. 81 84) and RAC1/TRIO (No. 85), show similarities only to themselves or only within clusters.
For example, in Supplementary Table S4, all instances in the cluster of EGFR/GRB2 and GRB2/MET show slight similarities (scores of 258 825) to STAT3/STAT3 (see No. 43 60 in row and No. 92 in column).
Some will call for more effective implementation of the existing provisions (perhaps by stricter sanctions), others for supplementary regulations (for instance on more transparent product tracking and labelling) and some will want wider public debate.
First, the most radical strategy would be to completely remove the prevailing links between basic and supplementary insurance, for instance by a legal requirement that both types of insurance have to offered by strictly separated legal entities.
In spite of lysosomal turnover after DFP (Fig 2C), BNIP3 small interfering RNA (siRNA) depletion did not influence mitophagy suggesting it is dispensable in this instance (supplementary Fig S3C,D online).
With care providers' funding currently depending almost solely on DRGs (their penetration rate increased from 10% in 2004 to 100% in 2011 for French public hospitals, the highest in Europe) [ 67] and other supplementary payments, for instance for research and training, hospitals are rewarded, or punished, for their economizing behavior.
For instance, in Supplementary Note 6, we present an example of the observation of self-rotation in graphene/graphene stack being seen via direct measurements of the electronic density of states in tunnelling experiments.
