The supplementary response improvements indicate that neurons in area 17 keep a memory trace of the previous stimulus properties, thereby upgrading cellular performance.
In addition to generating supplementary data, further improvements of the experimental design and analysis techniques could also contribute to the robustness of results.
Supporting the claim that theta power is mechanistically liked to cognitive control, ON OFF theta power changes at the single subject level correlated with subjects' RT improvement (Supplementary Fig. 6).
There appears to be a negative relationship between SNR and improvement (Supplementary Fig. S2).
Further supplement of the VCR set with any other reprogramming-promoting compound showed no significant improvement (Supplementary information, Figure S2B).
In this test, the piET algorithm performed slightly better, with a small improvement (Supplementary Fig. S5) in area under the curve (compared with ).
In contrast, when the same viral construct was injected into the ST through the RW membrane (n = 7), no injected mice showed significant hearing improvement (Supplementary Fig S2B).
Similarly, when PCA was applied to the l6n1 signature with the Euclidean distance metric, a large reduction in the dimensionality was observed (38 114 principal components explaining 97.81 99.96% variance), with no significant performance improvement (supplementary table S4, Supplementary Material online).
We found no significant differences in blood pressures among the groups or between WT and Rnd3+/− haploinsufficient mice, suggesting a minimal effect of vasodilation on the cardiac improvement (Supplementary Figure 1).
Of the revision studies (Table 2 see Supplementary data), the improvement in 2 studies remained lower than the cutoff point of the inter- and intra-observer variability of the KSS function score (Bedard et al. 2011).
