The effects of Ap4 loss on tumorigenesis observed in ApcMin mice were independent of the gender (Supplementary Fig. 2c-e).
rs62623713 maintained strong associations with BMI after adjustment for age or gender (Supplementary Table S8).
No significant association was found between miRNA (miR-1207-5p, miR-1266) expression and age or gender (Supplementary Table 4).
Statistical models incorporated measured sound peak volume (as a surrogate for perceived loudness; online Supplementary Material) and gender as nuisance covariates.
For synovium and fat pad, this meQTL was independent of gender (Supplementary Material, Fig. S4B), although we observed a reduction in fat pad methylation in males relative to females that was independent of genotype (P = 0.009; Supplementary Material, Fig. S4).
In regression analyses comparing the relative risk of incident and fatal CAD by gender (Supplementary Table 2), men versus women without diabetes had higher rates of CAD events; the results were significant for GeneSTAR (HR 2.33 [1.54–3.57]) and MESA HRR 3.23 [1.82–5.88]) but not NHANES (HR 1.20 [0.42–3.45]) in fully adjusted models.
Study 2 explicitly sought to recruit participants from a demographic background more representative of the general population than those in Study 1. Comparing the study samples revealed significant differences in BMI, age, and diet status, but not gender (Supplementary Table S1).
No significant differences in the duration or incidence of LRTI symptoms were observed between genders (Supplementary Table S2).
The statistical analyses were also conducted according to gender (see supplementary tables S1 and S2).
The two study groups were comparable with respect to WAA by PCA plot (Supplementary Figure 1) and gender (p = 0.463).
The systematic review included 9,559 COPD participants (range of mean age, 48 to 73 years), including 6,101 (63.8 %) men, 2,000 (20.9%%) women and 1,458 (15.3 %) without indicated gender (Electronic supplementary Table 2).
