An increase in life span of p53 null mutant flies relative to wild-type controls was obtained in female progeny regardless of cross direction (Supplementary Figure 4; Supplementary Table 8), thereby ruling out a primary effect of maternal genotype.
Compared with Dm test, the intense underestimation of θ s m ^ and θ π m ^ by D leads the test statistic closer to the neutral null distribution, whereas much stronger underestimation of θ s m ^ than θ π m ^ by Dmod leads the test statistic farther toward positive direction (supplementary table S4, Supplementary Material online).
TD was thus only performed in one cross direction (supplementary table S1 and fig. S1, Supplementary Material online).
They are highly dynamic, oscillate back and forth, and repeatedly change direction (Supplementary information, Figure S6, top row; Movie S6).
The PF-10 was associated with objective physical performance in the expected direction (Supplementary data available in Age and Ageing online, Table S1).
The migratory Cer1-expressing cells assembled into string-like configurations, extending in a distal-to-proximal direction (Supplementary information, Figure S1E).
The tomographic reconstruction has inherent isotropic resolution: the sample could be virtually sectioned and visualized along any desired direction (supplementary material Movie 2).
The phosphate moiety of FHP overlaps with the β-phosphates of 2F-FPPs, although the farnesyl chain is more extended and folds in essentially the opposite direction (Supplementary Figure S4).
We found no evidence of such an effect (fitting a linear model with X-linkage and sex-bias as factors to the log-transformed data shows a significant interaction between these factors, but in the wrong direction; see supplementary table S5, Supplementary Material online).
Motifs of 10 units or more represent robust, mature microsatellites that display the attribute of dynamic mutation equally in both directions (supplementary fig. S4 B, Supplementary Material online).
As expected, this change was in opposite directions (supplementary table S6, Supplementary Material online): Expression of MCT1 increased after turning the Reb1p binding site nonfunctional, but decreased after targeting the Ndt80p binding site.
