The sequence alignments and other supplementary data are presented elsewhere [ 90].
qRT-PCR primers are as in supplementary table S1, Supplementary Material online, and statistical analysis of data is presented in supplementary table S2, Supplementary Material online.
A117T and E246K were observed in the same compound heterozygote (26) and in one of the most severe clinical cases (see Table 1 and Supplementary Material, Table S1), but no biochemical data were presented (see Supplementary Material, Table S2).
These data are presented in supplementary material S2, Supplementary Material online.
The main results are summarized in table 1 and a complete list of the data is presented in supplementary table S6, Supplementary Material online.
The cosmogenic nuclide data are presented in Supplementary Data 1 3, and Supplementary Figs 1–4.
The late start of the growing season in May 2010 in Schluchsee was also revealed by the phenology data for bud development (Supplementary Table S1), and in Supplementary Figures S1 S5, where the physiological data are presented by campaign and field site.
Additional 2P-STS data are presented in Supplementary Fig. 2 4.
Detailed NGS data are presented in Supplementary Data 2 and 3. To efficiently perform simultaneous multiple gene knock-ins, we constructed an integrated multiplex donor vector that produces three kinds of PITCh donor fragments carrying mNeonGreen, mKate218, and TagBFP19, targeting three different gene loci (Fig. 3a, Supplementary Fig. 14a).
Thus, a subsequent re-sintering at 1,000 °C for ~ 100 h was performed to complete the reaction (the XRD data are presented in Supplementary Fig. 8), after which the collected powder sample was employed for the assessment of Mg mobility.
All rocaglates identified in our primary screen (C9433, C8808, C5557 and C8809, Fig. 6) inhibited protein translation (Figs 3c and 5c), suppressed NO production and induced autophagy (the C8808 and C5557 data are presented in Supplementary Fig. S6).
