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Correlation analyses indicated that disease duration and HOMA-IR, instead of hyperglycaemic indices themselves (FPG and HbA1c), were the main contributors to these impaired performance (Supplementary Table  2).> -wrap-foot> Dare arepresentedted as mean ± SD, n or median (range).

Likewise, synthetic interactions do not appear to be a major contributor to arsenite toxicity (Fig. 5E; supplementary material Fig. S3).

However, the contribution varies with the type of feed and availability of natural sources, for example plant material at Topaz Farm was a greater contributor with 43.9 ± 19.5 % compared to supplementary sources raw corn 8.20 ± 3.10 and lupin 1.60 ± 1.70%%.

Furthermore, subretinal MP accumulation in 12-month-old Cx3cr1 +/GFP and Cx3cr1 GFP/GFP littermates of Cx3cr1 +/GFP breeders showed no evidence of influence from an unknown contributor gene specific to the Cx3cr1 GFP/GFP mouse line (Supplementary Fig S4).

The uniformity in expression of top candidate genes suggests that presence of other known mutations (for example, NPM1 and IDH1) may not be a major contributor to expression differences observed between FLT3/ITDH-AR and FLT3/WT samples (Supplementary Table 1).

The main contributor to the significant difference in thromboembolic events in the recent period was reduced risk of DVT (Supplementary data, Appendix 2).

Supplementary Material.

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