Interestingly, TFs that were mainly modelled by their gene expression were much lower connected (Supplementary Table S1).
Three hundred and fifty-six of these interactions (215 activatory, 74 inhibitory, and 67 undirected; supplementary table S17, Supplementary Material online) connect an IT pathway component with a non-IT pathway component.
BCL10 was among the top 10 most significantly correlated gene with other leprosy known loci (P = 6.07 × 10−4, Supplementary Material, Table S6), connected mostly through TNFSF15, RIPK2, CYLD and NOD2 (Supplementary Material, Fig. S2).
All cancers are connected together (Supplementary Figure S2), suggesting that various cancers may share similar associations at the miRNA level, in which some strong onco-miRNAs or miRNA suppressors may play key roles.
Dysregulated miRNAs and their targets or potential target mRNAs including the already known and our prediction were connected in Supplementary Material, Figure S3.
Please note that, because gene symbols for rodents and macaques differ in which typecase is used, we will refer to genes in uppercase throughout this paper and supplementary data to connect to conventions for writing human gene symbols.
We filtered the PIN1 network by removing self-interactions (giving rise to the PIN2 network, consisting of 8,280 proteins connected by 29,611 interactions; supplementary fig. S1, Supplementary Material online) and both self-interactions and interactions among proteins encoded by paralogous genes (PIN3, 8,189 proteins and 29,059 interactions; supplementary fig. S1, Supplementary Material online).
The OFC was structurally connected with the supplementary motor area (SMA) and activation in these two areas was correlated with faster stimulus evaluation during repetition priming.
After that, the complete set of 43,845 'decontaminated and rescued' sequences, which had a total length of 829.0 Mb (Supplementary Table S2), were further connected as super-scaffolds by using the Illumina MP reads and SSPACE 2.0.
These genes function in nearly all key steps in the GS pathway (Supplementary Fig. S1), and all were connected to the some extent, with BAT5 (Supplementary Fig. S8).
From this network a number of highly connected 'hub genes' were identified (supplementary material Fig. S1).
