We also found a significant signal with clinical vitamin D deficiency [i.e. 25(OH D <25 nmol/l] for GC (one risk allele OR = 1.83; P = 2.5 × 10−8), and weak or null associations for C10orf88 (OR 1.17; P = 8.1 × 10−2), NADSYN1/DHCR7 (OR 1.18; P = 0.11) and CYP2R1 (OR 0.89; P = 0.21), based on 2907 subjects in ATBC, PLCO, CPS-II and CLUE II (Supplementary Material, Table S2).
Even if these predictions cannot be transferred directly without supplementary bioinformatics analyses or experiments, they give strong clues on protein candidates for local orphan enzymes.
The clinical features of patients with CMS that David Beeson identified, including many with Dok-7 mutations, were characterized (Supplementary material B275), and Georgina Burke documented useful clinical clues to the diagnoses of AChR and rapsyn deficiencies (Supplementary materials B246 and B256).
This model recapitulates neurodevelopmental features of DS and provides important clues to the physiopathology of the disease (supplementary Fig S11).
The structural comparison between MABP-1⋅AMPPNP and MABP-1⋅erythrmoycin may provide some clues to this hypothesis (Fig. S8 and Supplementary Materials).
A sensitivity analysis of 1312 non-cancer case controls in ATBC, CPS-II, CLUE II and PLCO gave similar β estimates (Supplementary Material, Table S1).
Using natural-language-processing algorithms developed in-house, as well as supplementary algorithms provided by the company MetaCarta, the site searches the text of regular news stories for clues about associated locations.
Disease progression, age at onset, additional symptoms and results from other supplementary investigations such as cerebrospinal fluid (CSF) analyses, blood biochemistry and serology, electroneuromyography and ophthalmological examination can give important clues to the diagnosis (Table 1).
Of interest, our preliminary results also suggest that 10 μ M Ribavirin can decrease AKT phosphorylation and survival clues provided by a stromal feeder layer in a similar manner to the PI3K inhibitor BKM-120 (Supplementary Figure 1a and b).
