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It is therefore likely that the performance of the algorithm could be improved further by adding a supplementary check of the coding of pathology reports.
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Finally, data processed post-event can then be used for de-briefing purposes and supplementary validation checks.
Total 107 genes were grouped into pattern I and 94 genes were grouped into pattern II (please check supplementary files for details of two gene lists in Supplementary Material available online at http://dx.doi.org/10.1155/2015/878546).org/10.1155/2015/878546
To access EPI of a specific gene of the presented networks the reader can check supplementary tables S7 and S8.
In cases where the number of true negatives is large, it is advisable to use 'precision vs recall' curves instead of standard ROC curves ('recall' versus 'false positive rate') (Davis and Goadrich, 2006), for more details check (Supplementary Methods).
These three regions were manually checked (supplementary fig. S7, Supplementary Material online).
The expression and cellular localization of Lon-myc in 293/Lon were checked (Supplementary Figures S1A and B).
Goodness of fit plots, visual predictive checks (Supplementary Figures S3 and S4 online), and parameter estimates were considered as model evaluation criteria.
Article full-texts, figures and supplementary files were checked for unambiguous reporting of the sequence(s) of the investigated miRNA(s).
The visual predictive checks (Supplementary Material online) for the PK/PD model showed that the effect compartment model was able to reasonably describe the data.
Detailed protein data are provided in Supplementary Table 2. To check for outliers, unsupervised assessment was performed using PCA and no significant outlier was identified.
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