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We also considered a supplementary categorization according to age, i.e., earliest death of a parent at ages 0 <3 years, 3 <13 years, 13 <18 years and 18+ years.
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Histopathological categorization (see Supplementary Table 1) and histopathological grading according to the Shimada classification were carried out following INPC instructions.
The analysis selected catabolic genes rather than metabolic genes (Supplementary Table S3) because categorization and included genes were different from PANTHER, supporting that these analyses did not identify a specific function.
Similarly, for known HSA21 genes putative extended UTRs and novel splice junctions according to our categorization method were also detected (Supplementary Files S3 and S4).
The combinations of prognostic and predictive categorizations are shown in supplementary Table 1.
A full list of the foods and their UK food guide categorizations are available in Supplementary Materials.
This binary distinction between universal and nonuniversal orthologous groups as well as between single-copy and multicopy orthologous groups was chosen for simplicity and consistency over alternative (stricter and possibly more intuitive) categorizations presented in the Supplementary Material online that support the same conclusions (supplementary figs. 1– 3, Supplementary Material online).
Supplementary Table S1C and D describes the categorization of the CCGG segments based on the genome annotations.
These categories are made up of constituent causes of death and the categorization is shown in a Supplementary file, where constituent causes of death are ordered by rank of frequency.
See the Supplementary Data for a listing of chronic comorbid illnesses used for CCIG categorization.
To avoid the negative effects of categorization, we analyzed the effect of competing factors on raw pBLS estimates using different association measures (supplementary table S2, Supplementary Material online), although only the values of the Spearman's rank correlation coefficient are reported throughout the manuscript.
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