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Population denominators were derived from the 1981 census and supplementary birth registration data.
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Despite the similar initial clinical phenotype, the disease followed a clearly different course for each patient after birth (Supplementary Information).
Col IV staining indicated an intact and apparently normal bronchial epithelial basement membrane at birth (supplementary material Fig. S1F).
On age-adjusted Spearman correlation analysis (Supplementary Table 1), birth weight was associated with HOMA-IR in infants of women without GDM (r = 0.32, P = 0.02) but not in infants of women with GDM (r = −0.18, P = 0.34).
The acquisition of mechanosensitivity coincided with significant morphological changes, so that the median cell diameter of the smallest neurons increased rapidly between E15.5 and birth (Supplementary Figure S2A, red dashed line).
To address this concern we conducted a supplementary analysis of birth certificate data for all women who delivered preterm infants at the hospitals where women were recruited, during the same time period active recruitment occurred.
To investigate the molecular mechanisms regulating the balance between survival and death, we compared gene expression profiles in control and TIF-IAD1RCre mice at the early and late phase of p53 increase, that is, at 9 and 13 weeks after birth (Supplementary Figures 6A C).
The successive exploitation of these tests to avoid carrier mating immediately dropped the number of mutant births (supplementary material Fig. S5).
Online supplementary figure S2 compares birth weight in boys and girls in 54 studies and the MGRS.
Setting Patient data from multiple sclerosis prevalence surveys carried out in 1981 19811 Australian census (giving the total number of people born in Australia and still alive and living in Australia in 1981 by year of birth 1920-50); supplementAustralianlian birth registration data covering the same birth years by month and state.
We excluded pregnancies from the cohort if either chromosomal aberrations or congenital viral infections were reported in the birth registry (supplementary table A).
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