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A supplementary analysis will be per protocol for the TIPIT study.
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If there are any differences in the characteristics of women in the three groups which might be associated with the major outcomes, a supplementary multivariate analysis will be carried out.
If there are any baseline differences in the characteristics of women in the two groups, which might be associated with the major outcomes, a supplementary multivariate analysis will be carried out.
A supplementary multivariate analysis will be undertaken if there are any baseline differences in the characteristics of women in the two groups which might be associated with the primary outcomes.
Supplementary, a sensitivity analysis will be performed according to a per-protocol analysis in children adhering to the intervention protocol, and thus strict registration of participation will be conducted.
The full statistical analysis plan can be viewed in online supplementary appendix 7. The analysis will be based on intention-to-treat principles.
A preference-based single utility measure, using Australian preference weights, will be derived from SF-36 using the Short Form-6 Dimensions (SF-6D) as described by Norman et al. 41 A supplementary analysis using the EQ-5D-5L will also be conducted.
We find that the resulting estimates of h L 2 are on average 90% of the true values (Supplementary Fig. 5), indicating that heritability analysis will tend to moderately underestimate the total variance explained on the liability scale for low prevalence diseases.
Advancements in biorefining technologies along with the development of novel fermentation strategies and analysis will be paramount in order to establish supplementary and sustainable biofuel pathways.
No additional a priori adjustment of covariates or subgroup analysis will be performed; these issues will be explored further in supplementary analysis as part of the development of the statistical analysis plan for the larger trial.
A supplementary analysis (see below) was set to look at the Washington event.
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