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A supplementary analysis was performed where members of the control group was drawn as 10 random controls per case matched on calendar year of birth and hospital.
Supplementary analysis was performed to check the possible influence of partially missing data in the crude and Model I analyses, using the complete cases of Model II.
A further supplementary analysis was performed to test the hypothesis that the association between negative symptoms and clinical outcomes varies with age.
To order the genes according to their significance with regard to anxiety disorders, a supplementary analysis was performed to examine whether significant trends in associations could be detected across individual genes.
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A supplementary secondary data analysis was performed, applying qualitative content analysis with open coding.
A supplementary complete case analysis was performed to check possible influence of partially missing data in the crude and Model 1 analyses.
A supplementary propensity score matching analysis was performed comparing matched pairs of breast fed and not breast fed very preterm infants in each cohort.
Detailed procedures for metabolomics measurement are provided in the Supplementary Methods, but briefly, analysis was performed using AccQ-Tag derivatization and samples were analyzed by ultra performance liquid chromatography tandem mass spectrometry.
Primer sequences are provided in Supplementary file 2. ChIP analysis was performed as previously described (Viscardi et al., 2007).
The search results from the Global Proteome Machine site are provided in Worksheet 1, Supplementary Table 2. Statistical analysis was performed using GraphPad Prism v6 (GraphPad Software, Inc., La Jolla, CA, USA).
RT-PCR primer sequences are listed in Supplementary Table 2. Statistical analysis was performed with JMP 9.0.0 software, with data expressed as means ± SEM.
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