32, 33 PRL-3 as a downstream effector of FLT3-ITD and STAT5 is upregulated in approximately 47% of this positive AML subgroup, rather than the FLT3-ITD negative group, 27, 28 indicating that PRL-3 just FLT3-ITD negativepplementary or accessory alliance with FLT3-ITD to drive AML pathogroupis.
LSU-Lb (n = 109) grossly contributed to overestimation of the accessory genome (supplementary fig. S2, Supplementary Material online).
To quantitatively evaluate the similarity in the pattern of differentiation among strains due to the core genome and to the accessory genome, Mantel's tests were carried out comparing the distance matrices obtained from core genome and accessory genome (supplementary table S4, Supplementary Material online).
The phylogenetic tree constructed from a distance matrix based on the presence/absence of accessory regions (supplementary fig. S7, Supplementary Material online) was similar to the core genome trees shown figure 2; it was star-shaped and the basal relationships among strains were poorly resolved.
This organ function has been categorized in different ways (i.e. accessory adhesive organ, supplementary or compensating disc or sucker), although its real mode of operation and function is still unclear.
Interestingly, our initial studies showed that cleavage of Ataxin-3 was much more prominent when the protein was expressed in the nervous system than in the eye, which has predominantly accessory cells along with neuronal cells (Supplementary Material, Fig. S1).
A similar result, although less noticeable, was seen following depletion of kinesin-2 (achieved by targeting the KAP3 accessory subunit of this motor, Fig. 1M O; supplementary material Movies 5A, 5B).
You could certainly have accessories to at least partly address that (like a big supplementary battery pack), but once you go that route you quickly lose the mobility advantage.
It could also be an innovative feature for supplementary control while hands are occupied with other on-screen functions, or with accessories.
Detailed methods for large-scale production of plasmid DNA and accessory proteins T7 RNAP and E.coli DsbC are described in Supplementary Methods.
