Plasma cholesterol, glucose, and triglyceride levels in plasma samples taken from seven Knobloch patients were compared to six heterozygous carriers of the mutation and seven normal controls (see Methods for study inclusion criteria Supplemental Table S1).
The discriminative capacity of the DAS28 could only slightly be improved by the inclusion of supplemental variables in the regression model.
This study provides the basis for exploring optimization through such adjustments as variation of 'recent'/'nonrecent' thresholds, inclusion of supplemental tests (in particular, viral load), and the use of multiple incidence assays, all of which is the subject of ongoing work within and beyond CEPHIA [ 2, 4, 37, 47, 48].
HD is associated with increased iron in basal ganglia [ 45] and we found that supplemental iron exaggerate polyglutamine inclusions as well as impaired the motility of a C. elegans PolyQ transgenic model.
Some countries used methods supplemental to coded diagnoses or other inclusion methods introducing potential inclusion bias.
Results Eight randomised controlled trials (n=2426) of supplemental vitamin D met our inclusion criteria.
Within the EPIC study, results were consistent (Supplemental Table S3), and the inclusion of the EPIC study within the meta-analysis also showed consistent patterns but inflated the level of heterogeneity (Supplemental Table S7, Supplemental Figure S9).
Informed consent for all procedures was obtained as standard procedure required and supplemental written acknowledgement on the inclusion in the study was given prior to manipulation and interpretation of the histological fragments.
Electronic search results yielded a total of 33 citations; of these only 12 met the inclusion criteria [see Supplemental Material, Table 2 (doi:10.1289/ehp.1002077) for citations of excluded articles and the reasons for exclusion].
However, none of the postnatal phthalate metabolite concentrations were associated with child asthma (see Supplemental Material, Table S2), and inclusion caused < 10% change in effect size of predictor variables.
