To estimate additional resource use not captured on an individual level in the cohort study, we developed supplemental data collection forms after five focus groups held with midwives from all parts of England early in the project.
In addition, slight differences were observed between the DG-100 used in the HCTLS and the BT-Q1000x used in supplemental data collection; BT-Q1000x had a shorter acquisition time at cold start in an indoor environment, lower rate of data loss, but slightly poorer performance in spatial accuracy [ 24].
Participants with prevalent cardiovascular disease (n = 634) at the time of supplemental questionnaire collections were excluded from the analysis.
The diurnal plasma corticosterone results are somewhat confounded by the effects of stress in blood collection (Supplemental Figure 1).
Data were collected on the ID23-1, ID23-2, or ID29 beamlines at the European Synchrotron Radiation Facility (Grenoble, France) and processed as described in Supplemental Material, "Data collection and structure determination".
Supplemental survey data collection and management will be conducted according to the standard procedures used for the standard bi-annual surveys and is described in above.
We also checked the effect of the missed collections on the variation pattern of urinary BPA in spot samples by comparing the variance apportionment of urinary BPA concentrations in spot samples with and without participant 2, who had the largest number of missed collections [see Supplemental Material, Table 1 (doi:10.1289/ehp.1002701)].
Detailed information on animal and human sample collections and data collection is provided in Supplemental Information, which includes Supplemental Methods, brief descriptions and rationales of the framework, discussion on COPD data sets used in the current study, Supplemental Figures, Supplemental Tables, and References.
In addition, hematocrits, leukocyte counts, and platelet counts were determined for each collection of blood (Supplemental Tables 1 3).
The goal of the collection of the supplemental isolates was to identify and study the mechanism of resistance in INHR clinical isolates that lacked any canonical mutations in katG and inhA promoter.
