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The animals were housed in accordance with the guidelines for care and use of animals in scientific research (Indian National Science Academy, New Delhi, India) in a CPCSEA (Committee for the purpose of control and supervision of experiment on animals) registered animal facility.
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XRZ participated in the experimental design, performed experiments, CCW, AGG and SPS also participated in the experimental design and writing of manuscript, LL participated in manuscript preparation and supervision of experiments, QL participated in the experimental design, performed experiments, supervised all procedures, analysed data and wrote the manuscript.
All the experimental procedures were performed according to the committee for the purpose of control and supervision of experiments on animals, norms and approved by the Institutional Animal Ethical Committee.
All the experimental procedures were performed according to the committee for the purpose of control and supervision of experiments on animals, norms and approved by the University of Port Harcourt Animal Ethical Committee with an approval number UNIPORT/PHARM/0133.
LBF participated in planning and supervision of experiments.
LGS participated in conception of the study and supervision of experiments.
BMD conception and design of the study, supervision of experiments and helped to draft the manuscript.
TW participated in supervision of experiments and revised the manuscript critically.
I.M.R. was involved in project design, supervision of experiments and manuscript preparation.
OTM was involved in the conception and design of the study and the supervision of experiments.
LMZ was involved in the conception and design of the study and the supervision of experiments.
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