MK trained and supervised the local counselors, supervised therapies, and organized and supervised post-treatment assessments.
Over 40% of patients in both the self-supervised therapy and the DOT arm failed to complete therapy [ 17, 18].
Enrolment of 80% of the population in the vaccinated group and 54% in the comparison group, who were also involved in OM-RCT with more restrictive inclusion criteria and supervised therapy, introduced selection bias against a positive vaccine effect.
Currently, Medicare provides limited benefits for rehabilitation, and funding for supervised therapy is especially meagre.
After 12 weeks of supervised therapy, patients were encouraged to continue stretching and strengthening exercises at home (all exercises listed in Table 2, except cycling) once a day for 5 days a week.
The following Medical Subject Heading terms and strategy was used: directly observed therapy OR supervised therapy OR directly observed treatment strategy OR DOT OR DOTS AND self-administered therapy OR self-supervised therapy OR unsupervised therapy AND tuberculosis.
In addition to providing supervised therapy to cases, new tools to prevent infection and reduce transmission are required to accelerate progress in TB control [3].
Of the 186 treated patients, 55% received strict directly observed therapy, and 25% others received a less intensive form of supervised therapy.
This result is consistent with those from other effectiveness studies, showing that unsupervised treatment with artemether-lumefantrine had the same efficacy (98%) as supervised therapy for the treatment of uncomplicated malaria in Uganda 33 and that artemether-lumefantrine had excellent effectiveness in a region of Tanzania with high rates of treatment failure with other antimalarial drugs.
CC developed the design, trained the local counselors, supervised therapies, supervised the post-treatment assessments, performed the statistical analysis and drafted the manuscript.
