In terms of reliability, there was no superiority of studies with a larger sample size and longer duration as compared to smaller studies.
The superiority of this study is that we built the relation between the spectral changes of MPBA (relative intensities) in molecular recognition with the sialoglycan dynamic expression of cells.
However, demonstrating superiority of the study intervention on a single endpoint would have required such a large sample size as to compromise feasibility of the trial.
Also, the temperature distribution, fin performances and optimum design parameters obtained from the present analysis are compared with that from the published analysis and significant differences are noticed due to the superiority of the present study.
Study HGKB was an open label extension safety study offered to patients who completed or discontinued from study HGKA, study HGJZ (investigating superiority of OLAI vs. placebo), or study LOBS (investigating product performance and bioavailability of OLAI).
These discrepant results are presumably explained by the superiority of TEE for studying pulmonary venous flow [ 12, 19], as reflected by the exclusion of 29% of eligible patients from data analysis in the study by Boussuges et al. due to poor imaging quality [ 15].
According to Egger's test, there is a significant "small study effect", smaller studies reported more pronounced superiority of DES compared to larger studies (bias estimate Egger's test: −1.71, standard error 0.77, slope 0.24, p = 0.034, Figure S3).
Finally, a comparative study has also been made between the present and published results, and for every case study, superiority of results obtained from the present model is noticed and the degree of supremacy increases with the increase in condensation rate of vapor on fin surfaces.
The superiority of afatinib in this study encourages further investigation on the therapeutic potential of afatinib as a single agent or in combination with gemcitabine in pancreatic cancer.
An elegant demonstration of the superiority of an isogenic cell line study design over a study design comparing iPSC lines from patients versus control individuals was provided by a recent study of a mutation in the LRRK2 gene, which is implicated in Parkinson disease (Reinhardt et al., 2013).
In the present study, the shorter time (6 months) needed to obtain significant difference demonstrated the superiority of MRI in such studies.
