The second-generation drug-eluting stents (DES) have shown superiority in many studies relating to safety and efficacy when compared with the first-generation DES.
The ideal treatment for intertrochanteric fractures is still under debate as none of the existing osteosynthetic devices could prove its superiority in former studies [ 16, 25, 29, 30].
Although IRI-S achieved longer median survival than S-1 monotherapy and was well tolerated, it did not show significant superiority in this study.
15 Varenicline maintained superiority in the second study with bupropion users achieving a CQR of 14.6% (P = 0.004).
The power of male superiority as reflected in studies showed that large percentages of both men and women believe that male violence against women are acceptable under different circumstances [ 7, 8, 15].
With respect to demonstration of superiority in a prospective, randomized study, it is important to realize that design features of such studies (most notably, that control patients must receive a therapy expected to be active) make superiority unlikely except in exceptional circumstances.
AVERROES was designed as a superiority study; in addition, it would replicate the findings of ARISTOTLE, provide additional insight into the benefit risk profile in the broadest possible AF patient population (i.e., those who were unsuitable for VKA, as well as those able to be treated with warfarin), and provide a superiority finding to reinforce a noninferiority outcome from ARISTOTLE.
However, the authors acknowledged that "the ability to predict clinical superiority in a head to head study on the basis of results from separate placebo-controlled studies of each drug might be restricted and is challenged by a trial population with low disease activity".
Despite this data were not confirmed by the Garcia-Granero group that demonstrated a PCT superiority in the AL diagnosis [ 50], both studies only study the AL complication and did not performed a time dependent analysis study.
While our study did not confirm Tulip's superiority in this respect, comparison with this study is problematic due to differences in setting, investigation level, purpose and methodology.
