Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration.
Currently available mechanical valves primarily provide durability whereas bioprosthetic valves have superior tissue compatibility but both lack remodelling and regenerative properties making their utility limited in paediatric patients.
MRI also has superior tissue characterization capabilities, and lesions such as masses can be characterized using a combination of T1-weighted (T2-weightedighT2W (T2W) and fat saturation sequences and contrast enhancement, both early (perfusion) and delayed.
Future scaffold-based regeneration strategies should be evidenced to have: (i) superior tissue regeneration capability with excellent long-term clinical outcomes, and (ii) comparable cost with the existing methods.
The foundational promises for this hypothesis pertain to two clinical facts: midurethral sling procedure is a gold standard treatment, and the knotless suture offer superior tissue holding or fixation strength originated from the unique barbed design.
Although dental pulp contains DPSCs with dentin/pulp regenerative capacity, developing tissue-derived SCAP showed a superior tissue regeneration potential than that of DPSCs.
