Previous studies have suggested that postmenopausal women with breast cancer who present with wild-type CYP2D6 may actually have similar or superior recurrence-free survival outcomes when given tamoxifen in place of aromatase inhibitors (AIs).
Literature demonstrates superior disease recurrence and progression rates for BCG, but the possible induction of a systemic inflammatory response has led some to shy away from the use of this live attenuated strain of Mycobacterium bovis in the immunosuppressed group of patients.
Later, we evaluate whether superior bone recurrence-free survival may convert into the overall survival advantage.
However, if bone scan has an appreciable role in the initial staging of esophageal squamous cell carcinoma, it is logical to expect significantly superior bone recurrence-free survival in patients receiving esophagectomy.
Three phase III trials demonstrated a superior biochemical recurrence-free survival (PSA-BFS) for adjuvant radiotherapy compared to surgery alone: EORTC 2291 [ 3], SWOG 8794 [ 4] and ARO 96 02 [ 5].
The PET/CT was superior in detecting recurrence (4 versus 2) as well as metastases in lymph node (17 versus 1), bone (91 versus 18), and lung (8 versus 6).
The actively cycling phenotype was a superior predictor of recurrence to Ki67 on univariate analysis (HR of 3.90 vs 2.77) and remained so after adjusting for Ki67 following multivariate analysis (HR=2.98 (1.29–6.91), P=0.011), using the median value of 24% as a cut point.
In trials to date, fidaxomicin has been safe and well tolerated, is minimally absorbed, is not associated with selection of antibiotic-resistant strains in vivo or in vitro, and is superior in reducing recurrences following vancomycin therapy.
In a study involving 832 people with stage iii colon cancer indicated that higher levels of self-reported physical activity approximately 6 months after completion of chemotherapy were associated with superior disease-free, recurrence-free and overall survival.
FDG-PET/CT demonsuperiorsuperior diagnostic performance for recurrence in lymph nodes whilst recurrences in the skeleton and liver are more reliably depicted by MRI (Fig. 1).
