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Superior potency to phlorizin was provided by examples containing TAMRA, BODIPY, Cy3B and NBD fluorophores.
Most furoxan-based plumbagin derivatives exhibited significantly superior potency compared to their parent compound.
Compounds 6a d exhibited superior potency, with IC50 values at nanomolar levels.
Indeed, a recent study exploring a panel of HDAC inhibitors for HIV activation using an in vitro latency assay demonstrated that Panobinostat displayed a significantly superior potency compared to Vorinostat43.
The superior potency of Proxison may also be due to the phenoxyl radical (the oxidized form of Proxison) being recycled by intracellular antioxidants, or other reductive pathways, back to Proxison, as occurs for vitamin E45.
It demonstrated superior potency than Sorafenib against eight different cell lines, and was equipotent to Sorafenib against COLO 205 colon cancer cell line.
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Moreover, they manifested superior potencies and efficacies than gefitinib across the most tested cell lines.
All the target compounds, except three amino derivatives 8g, h and 9h, demonstrated superior potencies against A375P to Sorafenib.
The data revealed that 2,4-difluorophenyl2,4-difluorophenyl-3-trifluoromethylphenyl (9d) urea compounds are the most active derivatives with significant efficacies and superior potencies than sorafenib in 36 and 12 cancer cell lines, respectively, belonging particularly to renal carcinoma cell (RCC), ovarian, and non small cell lung cancer (NSCL).
Li, T. S. et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.
We and others demonstrated that tumor-reactive CD4+ T cells expanded in vitro in the presence of IL-7 exhibit superior antitumor potency upon adoptive transfer50,51.
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