The primary endpoint (superior renal function in the CNI-free group [eGFR, Cockcroft-Gault 17]) was assessed by analysis of covariance (ANCOVA) with treatment and center as factors and eGFR at randomization as covariate (two-sided α = 0.05).
Our data suggest that frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura.
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From LOCF_ANCOVA analysis, one can only conclude that drug was superior to placebo at endpoint.
No arm was found superior at the primary endpoint (Table 2, Figure 4).
The study did not meet its primary endpoint of superior complete cytogenetic remission at 12 months (bosutinib 70%, imatinib 68%; P = 0.601) in the intent to treat population.
However, the 95% CIs of the point estimates overlap broadly for all predictors, and no single strategy emerged as clearly superior for any particular endpoint.
37 A post-hoc analysis of secondary endpoints suggested superior 60-day mortality results for the tolvaptan group as well (5.4% versus 8.7% mortality rate).
The three co-primary endpoints demonstrated superior efficacy of fluticasone/formoterol combination therapy compared to fluticasone, formoterol, and placebo, respectively (Table 2).
In addition, in the outpatient setting, a secondary endpoint, motavizumab was superior to palivizumab, effecting a 50% relative reduction of RSV-specific, medicattendedended, lower respiratory tract infections (2.0% vs 3.9%, respectively; P = 0.005) [ 20].
