Compared to a traditional subtenon injection, this drug film demonstrated superior therapeutic duration, better drug bioavailability in the choroid and retina, and better-targeted drug delivery ability.
This study demonstrated no benefits in either ORR (10.7% versus 9.8%) or OS (12.6 mo versus 10.7 mo), but a superior response duration was seen (35.8 versus 13.7 months).
Subsequently, a large, multicentre, randomised trial suggested that longer-duration warfarin (6 months) was superior to short-duration therapy (6 weeks).
Systematic evaluation of each functional component of the plasmid has resulted in an improved design, exhibiting superior levels and duration of lung gene expression.
When administered directly to the lung in a guinea pig tracheal potential difference (TPD) model, the dimeric compounds were found to have superior potency, longer duration of action in the lung, and significantly reduced extra-pulmonary exposure in comparison to the corresponding monomeric ENaC blockers, which have been evaluated in the clinic but shown to have dose-limiting kidney toxicity.
8 The vaccine was safe and immunogenic and some patients achieved an overall survival duration superior to other reports in the literature of melanoma patients.
Hulsegge et al. [ 32] were the only authors to define back pain as long lasting i.e. a duration superior to 1 month in the past year.
However, it should be noted that the AUCs were not high and that it remains debatable whether the discriminative ability of ≥30 minutes is clearly superior to other durations.
Brian Weeden, a former Air Force officer now with the Secure World Foundation, a private group based in Superior, Colo., said the duration of the X-37B's initial flight would probably depend on "how well it performs in orbit".
Bonelli et al. [13], in a randomized trial of reflex sympathetic dystrophy, found that the performance of intravenous guanethidine block is of longer duration, and superior to stellate ganglion block as regards some early pharmacological effects.
