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For the superficial zone, 5 10 individual cells were randomly chosen and analyzed in each sample.
Expressed superficial zone protein was 3-fold greater in the superficial zone population than in the growth zone population (p<0.01).
Superficial zone protein a specific marker for articular cartilage superficial zone chondrocytes increased with BMP-7 and/or TGF-β1 treatment in SP micromass cultures.
Grad, S. et al. Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds.
To investigate the role of the superficial zone in regulating the frictional response of articular cartilage.
Superficial zone protein (SZP) is a key mediator of boundary lubrication of articular cartilage in joints.
Consequently, steady-state volume of the superficial zone cell decreased with increasing pericellular fibril stiffness.
To determine the in vitro conditions which promote expression of superficial zone protein (SZP).
Only Alloderm and Medeor Matrix supported chemotaxis-driven cell invasion beyond the most superficial zone.
Superficial zone chondrocytes were found to be significantly stiffer than middle/deep zone chondrocytes.
Using this harvesting technique, the superficial zone has been separated from the underlying growth zone.
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