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The 48 hpf larval developing VNC region is complex and composed of at least three layers of cells formed by the superficial proliferating neuroectodermal cells, the slightly more internal undifferentiated neural precursors, and the internal differentiated neural cells [ 56, 57].
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Using light microscopic immunocytochemistry, specific immunostaining for the Lot1 protein was observed at postnatal days 2 to 7 in the superficial external granule layer composed primarily of proliferating neuronal precursor cells.
DCAMKL1-positive cells and proliferating cells shed into the lumen after superficial injury and re-appeared during the regenerative process, mainly in the superficial mucosa.
Focal epithelial hyperplasias were focal areas of proliferating glandular epithelium distinguished from adenomas because they were smaller, less discrete, and confined to the superficial mucosal epithelium.
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