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Summary estimates were calculated.
The summary estimates yielded an IRR 0.10 [0.04; 0.30] suggesting a 90%, incidence reduction.
To evaluate changes over time in summary estimates from meta-analyses of diagnostic accuracy studies.
Then, summary estimates of risk difference were then calculated using the random-effect model.
We used the DerSimonian and Laird model for random effects to obtain summary estimates across studies.
However, substantial degree of heterogeneity was observed in the summary estimates.
The summary estimates from the two analyses were compared.
When significant heterogeneity is present, summary estimates from meta-analyses are hard to interpret.
A fixed-effect model was used for calculations of summary estimates and their 95% CI.
In order to obtain weighted summary estimates we used random effects models (Stata 10.0).
Summary estimates of relative risk (RR) for non-fatal and fatal MIs were calculated with a random effects model.
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