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We did so by setting a constraint on interventions modelling the ICD-transition imposing that the sum of the interventions must be zero, i.e. the total number of deaths is the same before and after the removing interventions.
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In the subadditive synergy model, the aggregate outcome when the interventions act together is less than the sum of the individual interventions outcomes.
Rather, it is a test to determine whether one intervention is better than another (additive interaction would test whether the combined arm is greater than the sum of the independent intervention arms).
Solving the time series model without the constraint that the sum of the cause-specific interventions should be zero, resulted in an increase of the all-cause mortality rate after the classification change of 0.4%% (=516 deaths) for the Netherlands, 0.03 % (=35 deaths) for Canada and 0.2%% (=1,153 deaths) for Italy.
To assess how the optimum solutions change as a function of varying screening costs, we also change the screening costs while fix the sum of the screening and intervention costs as $1000.
The sum of planned interventions should be sufficient to achieve the expected results.
LPR is the result of cell metabolic functions and thus reflects the sum of all interventions.
This is equivalent to calculating a weighted average of the proportion eligible for each intervention that receives the intervention, where the weight applied to each proportion is the ratio of the number eligible for the specific intervention to the sum of the numbers of eligibles for all interventions.
A constraint was used to keep the sum of cause-specific interventions zero.
The sum of ICU therapeutic interventions was not discriminative for outcomes between elderly and less-old patients.
However, there was no significant difference in total direct costs, which is the sum of all intervention, non-health and health care costs (Table 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com