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Objective response rate (ORR) was defined as the sum of complete response and partial response (CR + PR).
Overall response rate (ie, sum of complete response, partial response, and stable disease) and duration of response.
Further, radiological assessment revealed that the sum of complete and partial response rates was <5% in both trials.
The primary end point of the study was clinical benefit, defined as the sum of complete responses (CR), partial responses (PR) and >24 weeks stable disease (SD).
Secondary endpoints included the assessment of the IM pharmacokinetics (PK) in combination with S, calculating the Overall Clinical Benefit (measured as the sum of complete response (CR), partial response (PR), and stable disease (SD)), and calculating time to disease progression.
The percentage of the overall number of cases achieving a complete response or partial response or the sum of complete response, partial response, and stable disease cases was defined as the observed response rate (RR) or disease control rate (DCR), respectively.
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For those who filled in only five or six items on the HADS-A and -D subscales, missing scores were substituted based on the sum of completed items multiplied by 7/5 or 7/6, respectively.
VOI 2. The urinary bladder as defined by the CT images is shown in Figure 4; it also shows the sum of the complete dynamic PET study (0 to 30 min).
However the proofs seem to be technically much more complicated since one has to represent the space of harmonic functions on as a quotient of a direct sum of the complete tensor product of spaces of harmonic functions with fewer variables, while we produced here a, somehow, direct proof.
The values of S 1, S 2, and S 3 are compared with the 1H-adjusteda ICRU elemental compositions for the adipose tissue of adult 2a in [13] which have the following values: 67.7% C, 31.5 O, and 0.8% N. 2. VOI 2. The urinary bladder as defined by the CT images is shown in Figure 4; it also shows the sum of the complete dynamic PET study (0 to 30 min).
Although a smaller concentration of irinotecan was used in the nanoencapsulated arm than in the free irinotecan arm, the sum of the complete and partial responses was found to be twice as large in the nanoliposomal arm (13.6% compared to 6.8%), and the disease control rates were found to be comparable in both arms (59.1% in the nanoliposomal irinotecan arm and 61.3% in the free irinotecan arm).
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