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We are unaware of any suitably powered studies in primary care evaluating the impact of brief, opportunistic smoking cessation advice delivered by nurses.
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The potential for cognitive frailty as a separate therapeutic entity for future physical frailty prevention requires further research with a suitably powered study over a longer follow-up period.
Further research is needed with a suitably powered study over a longer follow-up period with additional focus on pathogenic mechanisms to allow rapid translation of knowledge into useful therapeutic interventions.
Taking alpha 0.05 and beta 0.1, applying the Student t test, at least 78 participants were required for a suitably powered study (calculated on http://www.sealedenvelope.com/power/continuous-noninferior/).
More realistically it suggests the need for appropriately powered studies.
It would also be interesting to explore, in a suitably-powered study, whether there is any association with MTLE without hippocampal sclerosis.
The findings from our study require further mechanistic investigation and the potential clinical effects in HIV-infected patients need examining in suitably powered clinical studies.
Further targeted investigations of the circulating levels of the aforementioned factors in a suitably powered independent study cohort are required to robustly test this theory.
The magnitude of PMI has been linked to worse clinical outcomes post-CABG surgery; whether CsA therapy is able to impact on prognosis in this patient group is unknown and needs to be determined in a suitably powered clinical study.
Further study with a suitably powered sample against more sensitive screens is now required.
Further studies are needed for a suitably powered MR approach.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com