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To establish a suitable significance threshold, we examined 59 known breast cancer regions with no known association with PrCa prior to this analysis.
Chromosomal regions harboring QTL affecting the trait mean are located by the highest values of the test statistic above a suitable significance threshold (e.g., B roman and S en 2009).
In a polygenic trait, there will be some inconsistencies in the sharing of founder alleles and hence a linear mixed model can be used to evaluate the maximum-likelihood estimate (derived LOD score) for each genomic position with a suitable significance threshold to differentiate signal from noise.
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Sequences where the hit has suitable statistical significance values are selected and extracted for protein function assignment by searching against the NR protein database [ 28] using BLAST [ 18] to verify its probable function.
Just on that account, however, a last hurdle remains: finding a suitable criterion of significance for theoretical terms that allows the distinction between analytic and synthetic statements to be drawn in the non-observational, theoretical languages of science.
Without a suitable comparison, its significance is easily over-interpreted.
Given the sparse collection for some regions we felt that our data set was not suitable to infer significance of phylogeographic patterns observed using tests such as Nested Clade Analyses.
Data were not suitable for comparative significance testing.
Likewise, consensus structure prediction is also an ideal starting point for sRNA prediction; however, it has to be validated by a suitable measure of significance like thermodynamic stability.
In general, the rationale is to select some oligos from the input sequences, align them and score the resulting profile according to its conservation with a suitable measure of significance.
With the increasing K, a much easier distinguishment of MSE improvement can be observed, due to the increasing significance of suitable concerned-patterns with a larger K.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com