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The problem includes locating suitable hub facilities having adequate multiplexing capacity, and routing the demand traffic from various clients (end offices) through their hubs, or alternatively, through a special point of presence node, in order to minimize total costs.
This property makes the hubs ideal drug targets; by targeting a drug against a suitable hub or group of hubs, it is possible to break down the cellular network of an organism completely, which would result in the death of the organism.
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If there are no suitable hubs remaining then distribute the remaining reserves to isolated locations optimising contact with non-reserved sites.
Speaking on Tuesday, the leader of Kent County Council, Paul Carter said: "It seems clear that the government's intent is to do a scoping exercise to find the most suitable location for a hub airport.
Although large-scale PINs have already been experimentally determined for several species (and thus represent suitable training sets for hub-predicting bioinformatics approaches), in general, protein interaction data are still lacking for many organisms.
If hubs are not suitable to handle a certain shipments, the likelihood of transportation via these hubs will be reduced.
The smart system includes a cradle for receiving a cell phone and interfacing the phone to external systems such as peripherals, networks and other systems through a USB hub and other suitable connector interfaces.
The identification of such transcriptional hubs might provide suitable targets for the development of therapeutic strategies directed at modulating these expression signatures.
It also demands an "independent, evidence-based study to find a location for a hub airport or a suitable airport to expand into a hub for the long-term" which could clear the way for the consortium's proposal.
Thus, the GO-based hub classifier should be suitable for predicting highly-connected proteins, even in organisms that lack protein interaction data.
Simulations for S10C steel using various die and workpiece geometries were carried out, and completeness of filling and load requirements were compared to determine the forming condition most suitable for production of the clutch-hub.
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