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Suitable for sumatriptan?

Table 2 Assessment of subject suitability for triptan treatment by HCPs   UK studya Clinician Australian studya Clinician German studya Clinician   Suitable for sumatriptan?

A false-positive was defined as a subject considered suitable for sumatriptan or naratriptan by the pharmacist, but not by the clinician.

The pharmacist used the MQ to assess whether the subject had migraine and was potentially suitable for non-prescription treatment with sumatriptan (UK and Australia) or naratriptan (Germany).

The dissociation half-life of DHE on 5-HT1B and 5-HT1D receptors is approximately 10 times longer than that of sumatriptan (5-HT1B: 1.38 h for DHE vs. 0.17 h for sumatriptan; 5-HT1D: 1.28 h for DHE vs. 0.09 h for sumatriptan).

Second generation triptans such as zolmitriptan [13 15], naratriptan [16], rizatriptan [17 21] and more recently almotriptan [14, 22] and frovatriptan [23] have been also successfully tested: the different pharmacokinetic and pharmacodynamic features of these triptans as respect to sumatriptan potentially render them particularly suitable for treating menstrual migraine.

The UK and German regulatory authorities reviewed all relevant safety data and concluded that sumatriptan 50 mg and naratriptan 2.5 mg, respectively, are suitable for non-prescription use.

Therefore this model is not suitable for the testing of novel drugs, with a mechanism of action similar to sumatriptan.

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