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For a dry powder carrier platform to be suitable for pulmonary delivery of potent biomacromolecules, it has to be aerosolisable and capable of stabilising the biomacromolecules.
Through deagglomeration of these aggregates, it may be possible to obtain discrete uniform particles (1 5 μm) suitable for pulmonary therapy.
The aerosol generated from the modified HandiHaler increased to micrometer size (2.8 μm) suitable for pulmonary deposition, when exposed to simulated respiratory conditions, with negligible mouth throat (MT) deposition (2.6%).
Moreover, Cpd #15 proved to be suitable for pulmonary topical administration given its sustained lung retention (t1/2 = 6.5 h) and high pulmonary levels (>100-fold higher than plasma levels) upon intratracheal administration in rats.
For a dry powder formulation platform to be suitable for pulmonary delivery of potent biopharmaceuticals, e.g., proteins and peptides, it has to be not only efficiently and reproducibly aerosolisable, but also capable of creating a matrix suitable for stabilising the relevant biomacromolecules at temperatures appropriate for storage and distribution.
Whilst we still met our sample size, the mean aortic PWV at baseline was lower than previously reported and which was used in our power calculation [ 6], perhaps reflecting the characteristics of a subgroup of patients with COPD who are deemed suitable for pulmonary rehabilitation, but additionally a larger proportion were female.
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Positively charged dendrimers are a suitable carrier for pulmonary delivery of enoxaparin.
Despite numerous advances in the field, e.g. development of suitable methods for pulmonary administration of polymeric nanoparticles, a sufficient association of the therapeutic agent with the carrier system as well as drug release in a controlled fashion remain considerable challenges.
Overall seven patients were suitable for a pulmonary thrombendarterectomy.
SA-loaded SLMs were then produced by a hot emulsion technique followed by high-shear homogenisation and the manufacturing parameters were optimized using the experimental design methodology in order to reach a suitable particle size for pulmonary administration.
The physiological heat insulation created by air surrounding the tumor produces more effective thermal energy for complete cell necrosis [ 15]; therefore, RF ablation is thought to be a suitable treatment option for pulmonary malignancy.
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