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MENDEL [ 30] is a program that is suitable for linkage analysis with SNPs in large pedigrees.
Several programs are suitable for linkage analysis with bi-allelic markers.
Strict data integrity on the SNPs based on a genotyped population consisting of 525 individuals produced a total of 1,189 SNPs suitable for linkage mapping [ 15].
Medium -to high-throughput custom SNP genotyping technologies such as Illumina GoldenGate, KBiosciences KASPar and Sequenom iPlex, which differ in assay type, throughput, multiplexing and cost are suitable for linkage map construction [ 25].
About a third of our cohort was not aware of a FH of ADPKD at the time of clinic attendance and would therefore not have been suitable for linkage analysis.
The LD estimates were computed among all 1,167 SNPs using genotypic data on 995 oysters (the additional 660 oysters either have no pedigree information or belong to smaller families not suitable for linkage mapping).
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These measures have been recommended as suitable for record linkage [ 43], and have been used previously in record linkage studies [ 38].
Large families suitable for informative linkage studies are therefore scarce.
Introducing ligands with binding domains or groups suitable for covalent linkage would also be of great interest.
The purpose of this paper is to describe an extended deterministic record linkage strategy for situations where there is a general person identifier (e.g. an SLK) and several additional variables suitable for data linkage.
The purpose of this paper is to describe a stepwise deterministic record linkage strategy for situations where there is a general person identifier (e.g. an SLK) and several additional variables suitable for data linkage.
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