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Furthermore, this class of compounds are drug-like and suitable for further optimization and preclinical studies.
Preliminary structure activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.
All of these results indicated that compound 17 was considered to be a promising lead structure suitable for further optimization.
Therefore, the cationic dendrimers represent a group of potential lead compounds, suitable for further optimization and development as pore-blocking antitoxins.
Our findings show that Pd-BENSpm exhibits promising anticancer effects which render it suitable for further optimization to develop a new metal-based chemotherapeutic drug for breast cancer treatment.
In vitro high-throughput screening approaches utilizing technologies like fluorescence polarization (FP) or nuclear magnetic resonance (NMR) were quite effective in the discovery and selection of lead compounds suitable for further optimization and development.
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Unfortunately, total synthesis of allosamidin is difficult and expensive, making it not a suitable candidate for further optimization as a chemotherapeutical agent (Andersen et al. 2005).
First, various homologs were compared to identify the most suitable starting point for further optimization.
We consider these achiral inhibitors highly suitable as starting points for further optimization.
Because the resulting complicated fin efficiency expression is not convenient for further optimization calculations, the data from the present solutions is correlated for a suitable range of problem parameters.
The application of modeling approaches for timber has proven suitable for the analysis of such a type of timber beam-to-beam connection and, consequently, might be used for further optimization of this connection.
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