Sentence examples for suitable for further lead from inspiring English sources

The in vitro safety profiles of selected compounds were assessed and shown to be suitable for further lead optimization.

Rational chemical modifications of the hit allowed the disclosure of the first reported highly selective S1P4 antagonists with low nanomolar activity and adequate physicochemical properties suitable for further lead-optimization studies.

ELN475156 represents a validated foundation for further lead optimization to discover APP selective second generation GSIs with improved safety and drug like properties suitable for chronic AD therapy [ 60, 98, 103, 104].

In general, a low carrier concentration is suitable for further p-type and LED engineering [12].

Preliminary structure activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.

All of these results indicated that compound 17 was considered to be a promising lead structure suitable for further optimization.

Therefore, the cationic dendrimers represent a group of potential lead compounds, suitable for further optimization and development as pore-blocking antitoxins.

In vitro high-throughput screening approaches utilizing technologies like fluorescence polarization (FP) or nuclear magnetic resonance (NMR) were quite effective in the discovery and selection of lead compounds suitable for further optimization and development.

SPIII-5H novel class of inhibitors of HIV IN/LEDGF interaction and this lead molecule is suitable for further molecular modifications.

The development of labelling strategies leads to production of a radioligand suitable for further testing in the chosen model system.

The present study clearly demonstrates that 1,2,4-triazine ring exhibits promising antitumor activity and the double-drug optimization strategy led to identifying 3d as a potent c-Met kinase inhibitor suitable for further development.